GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its major substrate, the translational initiation issue eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to some conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to unique stimuli12, triggering the built-in ten